Covid-19 Series June 2020

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Our team went through many data sources and prepared COVID-19 response of the life sciences industry deck. We will keep sharing this deck monthly as new companies developing diagnostics, treatment and vaccine are joined to fight COVID-19. 

To download the deck, here is the link

Topics covered in the deck: 

  • Global Spread of the virus

The pandemic spreads incredibly quickly between people. More than 6m people infected in appr. 5 months

  • Basics about SARS-CoV-2 & COVID-19: 

Overview

•Origin: Possibly in wet animal market in Wuhan, China

•Disease: Coronavirus disease 2019 (COVID-19)

•Cause: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

•Strain: Same virus as SARS-CoV-1, which affected 8,000 people in 2002-03

•DNA Study (Feb-2020): 96% DNA match between bat coronavirus and human suggests link to humans is not direct but through intermediate host

•Target: Upper respiratory tract and can spread to lungs

Transmission & Mechanism

•Enters through nose, mouth, or eyes

•Attaches to cells in the respiratory tract producing a protein called ACE2

•It fuses with the cell and releases the RNA

•The hijacked infected cell will produce proteins based on the “instructions” from the virus’ RNA

•Each infected cell can release millions of copies of the virus before dying

Characteristics

•Virus appears highly transmissible - Average patient infects 1.6 to 2.4 other people

•Affects older patients and fatality rate in the 70s is 3-4 times larger than the average

Men are twice more likely to get infected than women


  • Impact of Coronavirus on Financial Markets

Global stock markets spooked by surge in cases


  • COVID-19 Response of the Life Sciences Industry

Leading companies have joined forces to strengthen the industry’s response against the COVID-19 pandemic

Diagnostics, Treatment and Vaccine 

  • Key impacts of the COVID-19 pandemic on Life Sciences Companies:

Slowdown of Economic Growth

Demand Disruption

Operations Disruption

Impact on Regulatory Function

Increase in Costs

Product Launch Delays

Virology Science

Clinical Trial Delays

  • Short Term Action Plan for Life Sciences Companies

Secure Core Operations

Prioritize Clinical Trials

Revise Operating Model

Reduce Dependencies/Risks

  • Long Term Action Plan for Life Sciences Companies

Re-evaluate Strategy Plans

Revise Operating Model

Boost Commercial Activities

Acquisitions & Divestments

Enterprise Risk Management

Resume R&D Activities

Ensure Business Continuity

  • How can London Strategy help?

Re-evaluate Strategy Plans

Revise Operating Model

Boost Commercial Activities

Acquisitions & Divestments

Enterprise Risk Management

Operational Improvement

Ensure Business Continuity

  • Response of the Life Sciences Industry

COVID-19 Response of the Life Sciences Industry Leading companies have joined forces to strengthen the industry’s response against the COVID-19 pandemic

1.     Diagnostics

Diagnostic Testing The most pressing and immediate need in the battle against COVID-19

2.     Treatments

Treatment Development Pharma companies and biotechs are racing to develop an effective treatment for the COVID-19

3.     Vaccine

Vaccine Life Sciences companies are ratcheting up their efforts with accelerated schedules for creating new vaccines


  • Details of the Virus

Basics about SARS-CoV-2 & COVID-19

Anatomy of the Virus: SARS-CoV-2

Cellular Pathogenesis of the Virus: SARS-CoV-2

Covid-19 Disease Progression and Multi-Organ Injuries

Three Clinical Phases of Covid-19 Infection and Disease Progression

Almost 90% of Covid-19 Hospital Admissions involve Comorbidities

Potential Therapeutic Targets for SARS-CoV-2


  • Charts & Insights

Daily Death Tolls by Country

Daily Deaths per Day by Country and Region

Mapping the Covid-19 outbreak

Covid-19 situation in Europe & US

Many Major Countries are still seeing rapid case growth.

Comparison of Tests, Cases and Deaths

Death rates 2020 vs Historical Averages by Country

Death rates 2020 vs Historical Averages by Urbans

Excess Mortality Since Region/Country’s First 50 Covid-19 Deaths

Total COVID-19 tests per 1,000 vs. GDP per capita

Comparison of Tests vs Cases

Comparison of Median Age and Death Rate

The Countries with Critical Care Beds vs Active Cases

Populations Impact on Countries’ Death Tolls

Lockdown Timing Impact on Countries’ Death Tolls

Covid-19 Major Events in Global

Timeline of US Government Responses to Covid-19

Timeline of EU5 Government Responses to Covid-19

Entering lockdown and lockdown easing, by country

The Public-Health Tools and Approaches

Places Restricting Travel Because of the Outbreak

COVID-19 reported infections in EU5 – by age